Impact of HLA-G 14 bp polymorphism and soluble HLA-G level on kidney graft outcome

the hla-g 14-bp insertion/ deletion polymorphism in recurrent spontaneous abortion among iranian women

hla-g is a non-classical hla class ib molecule with limited protein variability generated by  alternative  splicing.  hla-g   displays  immunotolerant   properties  and  hence  plays important roles in the maintenance of a successful pregnancy and maternal tolerance of the semiallogenic fetus. polymorphism of the hla-g gene may potentially affect the biological properties of the protein, and a ...

HLA-G is a component of the CLL escape repertoire to generate immune suppression: impact of HLA-G 14 bp (rs66554220) polymorphism

Association between HLA-G 14-bp insertion/deletion polymorphism and cancer risk: a meta-analysis.

PURPOSE A number of studies have investigated the association between human leukocyte antigen-G (HLA-G) 14-bp insertion/deletion polymorphism and cancer risk, but the results remain controversial. In this study we aimed to clarify whether this association really exists. METHODS We carried out a meta-analysis of 8 studies including 1179 cases and 2795 controls from PubMed and Chinese language ...

Impact of blood processing on estimation of soluble HLA-G.

HLA-G is a non-classical MHC class I antigen that functions as an immunomodulatory molecule. There are two forms of HLA-G antigens, soluble and membrane bound. Soluble HLA-G can be produced by translation of HLA-G transcripts (HLA-G5, -G6, -G7) and by shedding/proteolytic cleavage of membrane bound antigens (HLA-G1, -G2, -G3, -G4). Soluble as well as membrane bound HLA-G molecules have a direct...

The HLA-G 14-bp Insertion/ Deletion Polymorphism in Recurrent Spontaneous Abortion among Iranian Women

HLA-G is a non-classical HLA class Ib molecule with limited protein variability generated by alternative splicing. HLA-G displays immunotolerant properties and hence plays important roles in the maintenance of a successful pregnancy and maternal tolerance of the semiallogenic fetus. Polymorphism of the HLA-G gene may potentially affect the biological properties of the protein, and a 14-bp inser...